The Clinical Spectrum of Dementia in Movement Disorders

Abstract

It is estimated that in the next decade, dementia and movement disorders will become the second ranking cause of death after cardiovascular disease (1). Dementias and movement disorders are clinically and biologically overlapping manifestations of neurodegenerative disorders. Important areas of overlap are: (i) the spectrum of Alzheimer’s disease (AD), Parkinson’s disease (PD), dementia with Lewy bodies (DLB) (see Table 1); (ii) the spectrum of Pick’s disease (PiD), frontotemporal dementia (FTD), corticobasal degeneration (CBD), progressive supranuclear palsy (PSP), amyotrophic lateral sclerosis (ALS) (see Table 2); (iii) distinct etiologies including Huntington’s chorea (HD), CreutzfeldtJakob disease (CJD) and vascular dementia (see Table 3).