The clinical significance of sex hormone in assessment before liver transplantation of male patients

Abstract

Objective To explore the clinical significance of sex hormones imbalance in preoperative evaluation before liver transplantation.Methods Seventy-one male patients who received liver transplantation from June 2011 to June 2013 in the first affiliated hospital of Zhengzhou University were selected as the observation group.They were divided into liver cancer group (35 cases) and cirrhosis decompensation group (36 cases) according to the original diseases.Furthermore,20 healthy male cases served as as the control group.Serum prolactin (PRL),estradiol (E2) and testosterone (T) were measured by using radioimmunoassay,and the ratio of E2 to T was also calculated.Results The E2/T ratio in liver cancer group [(16.99 ±6.64) ng/μg] and cirrhosis decompensation group [(13.93 ± 3.31) ng/μg] was significantly increased as compared with control group [(6.79 ±2.21) ng/μg,P ＜0.05],and this reduction seemd to be significant in HCC group than in cirrhosis decompensation group.As compared with AFP ≥ 400 μg/Lgroup [(13.89 ± 3.37)ng/ μg],the level of E2/T in AFP ＜ 400 μg/L group [(19.07 ± 7.50) ng/μg] was higher with the difference being statistically significant (P ＜ O.05).Conclusion E2/T ratio can be used as a preoperative indicator to patients before liver transplantation.Sex hormones have the reference value in the diagnosis of incidental hepatic cellular cancer,especially for the patients with low AFP. Key words: Liver transplantation; Prolactin; Estradiol ; Testosterone; Estradiol/testosterone