The clinical significance of Serum BNP level before and after thrombolysis in the patients with ST-elevated myocardial infarction

Abstract

Objective Brain natriuretic peptide (BNP) before and after thrombolysis in the patients with ST-elevated myocardial infarction(STEMI) were measured to explore their change characteristics and clinical significance.Methods 60 patients with a first ST -elevated myocardial infarction were divided into three groups :A group (non- thrombolysis n=18), B g-roup (non- reperfusion n=11) and C group (reperfusion n=31).the serum BNP at the hospitalized time,on24th hour and on the 5th day after ons-et of AMI wered measured with a immmunofluorescence assay provided by Triage Biosite, and then the consequences were compared between and in the groups. Results in the three groups :The levels of serum BN-P on the 24th hour and the 5th day were higher than those at the hos-pitalized time (P＜ 0.05), In the A and B groups,the serum BNP levels on the 5th day I were not different from those on 24th hour ,but in the -C group ,The levels of serum BNP on the 5th day were decreased sig-niticantly (P＜ 0.05) .between the groups: there are no diference in the the serum BNP levels at the hospitalized time.between the A and B grou-ps, the serum BNP levels both on the 24th hour and on the 5thday w-ere not diferent,but the serum BNP levels on the 24th hour and the 5th day of the two groups were higher than those of the reperfusion group(P＜ 0.05), Conclusion BNP measureme nt may help us evaluate the effi-cacy of thrombolysis,so it can offer evidence for assessing their condition, further treatment and the prognosis of AMI. Key words: Acute myocardial infarction (AMI); Thrombolysis; Brain natriuretic peptide(BNP)