Abstract

Background and aimSeveral aspects of the correlation between colon cancer and hemostatic markers are still unknown to many researchers in the field. In this study, we evaluated the association, if any, of preoperative platelet (PLT) counts and plasma fibrinogen levels with postoperative lymph node involvement and venous invasion in colon cancer patients.MethodsThis study retrospectively included eighty patients with colon cancer (mean age 58.09 years; 37% female 63% male).ResultsPatients with negative lymph nodes and venous invasion showed a significantly lower PLT count and higher fibrinogen level than their counterparts, i.e., patients with positive lymph nodes (p<0.001, all of them) and venous invasion (p<0.001, all of them). The results also showed a positive association of PLT counts and fibrinogen levels with lymphatic invasion (r=0.670, p<0.001 and r=0.639, p<0.001, respectively) and a positive association of PLT counts and fibrinogen levels with venous invasion (r=0.3988, p<0.001 and r=0.5268, p<0.001, respectively). According to the results of the ROC curve analysis, when the PLT count cutoff was 290/mm3, the sensitivity and specificity were 82% and 86.67%, respectively (AUC = 0.8840, p<0.0001, 95% CI 0.8084–0.9596). When the fibrinogen level cutoff was 310.0 mg/dL, the sensitivity and specificity were 72% and 96.67%, respectively (AUC 0.8790, p <0.0001, 95% CI 0.8067–0.9513).ConclusionThe preoperative PLT count and plasma fibrinogen level may be considered key markers to monitor postoperative lymph node involvement and venous invasion in colon cancer patients.

Highlights

  • Thrombocytosis and activation of the coagulation system are key prognostic factors in various types of malignancies, including colon cancer [1, 2]

  • According to the results of the Receiver operating characteristic (ROC) curve analysis, when the PLT count cutoff was 290/mm3, the sensitivity and specificity were 82% and 86.67%, respectively (AUC = 0.8840, p

  • The findings showed that preoperative PLT counts and plasma fibrinogen levels may be used as key markers to monitor postoperative lymph node involvement and venous invasion

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Summary

Introduction

Thrombocytosis and activation of the coagulation system are key prognostic factors in various types of malignancies, including colon cancer [1, 2]. In tumor metastasis, activated PLTs play a wide range of roles, such as facilitating tumor cell epithelialmesenchymal transition (EMT) and degrading the surrounding extracellular matrix (ECM). They improve vascular permeability and help establish malignancies in distant tissues. We evaluated the association, if any, of preoperative platelet (PLT) counts and plasma fibrinogen levels with postoperative lymph node involvement and venous invasion in colon cancer patients

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