Abstract
BackgroundIL-6 was associated with the severity of mycoplasma pneumoniae pneumonia (MPP). But the relationship between IL-27 and MPP was unknown.MethodsNinety-eight patients with MPP < 14 years old were enrolled in this study and divided into groups by severity (mild cases and severe cases), infection types (MP single infection group and MP mixed infection group) and DNA loads (low MP DNA loads group and high MP DNA loads group), respectively. Fifteen children with foreign bodies in bronchus were also enrolled as control. IL-6 s and IL-27 s in bronchoalveolar lavage fluids (BALFs) from these children were measured by ELISA.ResultsThere were significant differences in IL-6 s of BALFs from patients between mild cases and severe cases, MP single infection group and MP mixed infection group, and low MP DNA loads group and high MP DNA loads group, respectively (P < 0.05). Compared with IL-6 s of BALFs from control, IL-6 s in BALFs from the 6 patient groups were significantly higher (P < 0.05). IL-27 s in BALFs from MP mixed infection group were significantly lower than those from MP single infection group and control (P < 0.05) respectively.ConclusionIL-6 was firmly associated with MPP and had potential application in clinical practice while IL-27 was not related to MP infection.
Highlights
IL-6 was associated with the severity of mycoplasma pneumoniae pneumonia (MPP)
The whole patients could be divided into Mycoplasma pneumoniae (MP) single infection group and MP mixed infection group according to the infection types as well as low MP DNA loads (
General information From Jan 1st to Dec 31st of the year 2017, a total of 98 hospitalized children with MPP according to the including criteria and excluding criteria were enrolled
Summary
IL-6 was associated with the severity of mycoplasma pneumoniae pneumonia (MPP). Mycoplasma pneumoniae (MP) is one of the main pathogens in respiratory infections in children. It causes more than 40% of community-acquired pneumonia (CAP) cases in children, of which 18% cases need hospitalization [1]. IL-27 is another important cytokine which is firmly associated with IL-6. It can induce the secretion of IL-6 [9] and can block the activity of IL-6 by its subunit of IL-27 p28 [10], which plays dual roles of proinflammation and anti-inflammation. No reports have been found about whether there is any relationship between them in MPP
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