Abstract
PurposeTo investigate the significance of accompanying NME in invasive ductal carcinoma (IDC) on preoperative MR imaging and assess the factors affecting the significance.MethodsBetween January 2015 and February 2016, 163 consecutive patients with IDC who underwent preoperative MR imaging and subsequent surgery were enrolled and reviewed. Index cancer mass size and total extent with accompanying NME on MR images was measured and compared with pathologic size. Positive NME was defined as pathological result of IDC or DCIS. To identify affecting factors associated with frequency of accompanying NME on MR and positive pathologic result, clinicopathologic features were compared between breast cancers with NME and without NME, and between breast cancers with positive NME and negative NME using the Student t-test or Chi-square test.ResultsOf the 163 invasive breast cancers, 123(75.5%) cancers presented as only mass feature and 40(24.5%) cancers had accompanying NME around the index mass. Of the 40 accompanying NME, 22 (55%) had positive pathologic results and 18 (45%) had negative results. The HER2 positive status was significantly associated with positive pathologic results of accompanying NME (P = .016).ConclusionAccompanying NME on preoperative MR imaging showed malignant pathologic results in 55%. The HER2 positive IDC was more frequently accompanied by malignant NME.
Highlights
Preoperative breast magnetic resonance (MR) imaging has been routinely used for extent of disease assessment in patients with newly diagnosed breast cancer
Of the 163 invasive breast cancers, 123(75.5%) cancers presented as only mass feature and 40(24.5%) cancers had accompanying nonmass enhancement (NME) around the index mass
The HER2 positive invasive ductal carcinoma (IDC) was more frequently accompanied by malignant NME
Summary
Preoperative breast magnetic resonance (MR) imaging has been routinely used for extent of disease assessment in patients with newly diagnosed breast cancer. MR imaging offers more accurate local extent of invasive breast cancer and in situ tumors than ultrasound and mammography [6,7]. Recent study reported that DCIS histology was strongly associated with discordance between MR imaging and pathology size of breast cancer [11]. The invasive ductal carcinoma (IDC) most commonly presents as an enhancing mass on MR images, it is occasionally associated with NME surrounding the index breast cancer mass. The purpose of this study was to investigate the significance of accompanying NME in invasive ductal breast cancer on preoperative MR imaging and assess the factors affecting the significance
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