Abstract
Background: Data suggest cystatin C (CysC) levels and hepatic artery resistive index (HARI) correspond to the progression of chronic liver disease. We aimed to evaluate the clinical significance of these parameters in assessment of fibrosis in patients with liver cirrhosis. Methods: The cross-sectional study included 63 patients with liver cirrhosis. A control group consisted of 30 age- and gender-matched healthy persons. Results: We confirmed significantly higher values of CysC in patients with cirrhosis compared to control group (p = 0.036). Average value of HARI in the examined group was increased (0.72 ± 0.06) and there was the statistically significant difference compared to controls (0.66 ± 0.03) (p < 0.001). We found statistically significant correlation between HARI and CysC in the study group. Analyzing the possibility of distinguishing healthy subjects from patients with fibrosis, we have found that the area under the curve is far greater in the HARI index than CysC. Comparison of CysC among Child–Pugh stages and correlation with a model for end-stage liver disease (MELD) score showed statistically significant results. Conclusion: We confirmed HARI is a more accurate parameter than CysC in discriminating healthy subjects from patients with fibrosis, while CysC could be a better indicator of the stage of liver cirrhosis.
Highlights
Liver cirrhosis is the common pathological state of liver damage arising from a wide variety of chronic liver diseases
Our research aimed to evaluate the clinical significance of cystatin C (CysC) and hepatic artery resistive index (HARI) in the assessment of hepatic fibrosis in patients with liver cirrhosis
The average diameter of the portal vein, HARI and CysC were significantly larger in the study group, while blood flow velocity was significantly slower (Table 1)
Summary
Liver cirrhosis is the common pathological state of liver damage arising from a wide variety of chronic liver diseases. Liver cirrhosis is recognized as a leading cause of death with portal hypertension (PHT) being the most common complication of the disease. The most relevant determinant of PHT in cirrhosis is the increased intrahepatic vascular resistance as a consequence of liver vascular architecture distortion and hepatic sinusoidal cellular alterations that promote constriction of the hepatic sinusoids and fibrosis. Data suggest cystatin C (CysC) levels and hepatic artery resistive index (HARI) correspond to the progression of chronic liver disease. Results: We confirmed significantly higher values of CysC in patients with cirrhosis compared to control group (p = 0.036). Average value of HARI in the examined group was increased (0.72 ± 0.06) and there was the statistically significant difference compared to controls (0.66 ± 0.03) (p < 0.001).
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