Abstract
BackgroundTo examine the clinical features of radiation cataract in patients with ocular adnexal mucosa-associated lymphoid tissue (MALT) lymphoma.MethodsTwenty-one patients with 26 eyes diagnosed with ocular adnexal MALT lymphoma (26 eyes), who were treated in Hokkaido University Hospital, were retrospectively reviewed based on medical records.ResultsOut of the 21 patients, 16 patients (21 eyes) received radiation therapy (RT) with a total dose of 30 Gy. All cases eventually achieved complete remission. Eight of these patients (11 eyes: 52.3%) required cataract surgery after RT. The mean age at surgery was 56.8 (40–70) years. The mean latency between RT and the indication for surgery was 43.3 months. The percentage of females was significantly higher in patients who required surgery (P < 0.01), compared with those without surgery. The eyes of patients who received bolus technique on radiation treatment developed cataract more frequently (P < 0.05). In contrast, none of the patients without RT required cataract surgery.ConclusionsPatients with ocular adnexal MALT lymphoma who underwent surgery for radiation cataract were seen more often in relatively young, female patients, and surgery was required about 3 years after RT. A long-term observation may be needed for patients after RT for a tumor. A female sex and the bolus technique may be risk factors for radiation cataract.
Highlights
To examine the clinical features of radiation cataract in patients with ocular adnexal mucosa-associated lymphoid tissue (MALT) lymphoma
Several reports have shown the efficacy of radiation therapy (RT) against ocular adnexal MALT lymphoma, offering excellent local control with a favorable clinical course [2,3,4]
21 patients (26 eyes) with ocular adnexal MALT lymphoma were reviewed, who were treated in Hokkaido University Hospital, Department of Ophthalmology, Sapporo, Japan, from Nov. 2004 to Dec. 2011
Summary
To examine the clinical features of radiation cataract in patients with ocular adnexal mucosa-associated lymphoid tissue (MALT) lymphoma. Mucosa-associated lymphoid tissue (MALT) lymphoma is the most common subtype among primary ocular adnexal lymphomas, with a typically indolent nature [1]. Several reports have shown the efficacy of radiation therapy (RT) against ocular adnexal MALT lymphoma, offering excellent local control with a favorable clinical course [2,3,4]. Besides the efficacy, side effects such as cataract, dry eye, and retinopathy occur following radiotherapy [5]. Lens shielding and limitation of the radiation dose help reduce the risk of cataract formation [6,7,8]. The details of radiation cataract including the
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