The clinical efficacy of continuous veno-venous hemofiltration for multiple organ dysfunction syndrome in children

Abstract

Objective To investigate the efficacy of continuous veno-venous hemofiltration (CVVH)for children with multiple organ dysfunction syndrome (MODS). Methods 30 chilren were divide into treatment group (15 cases) and control group (15 cases) and received antibiotics,vasoactive drugs,nutritional therapy,maintenance of acid-base balance,and mechanical ventilation; the treatmetn group received additional CVVH. Serum levels of cytokines (TNF-α,IL-1,and IL-6) were detected at 0,24,and 48h in the treatment group,and at 0 and 48h in the control group. Mean arteril pressure,ventilator parameters,biochemical indices,blood gas analysis,and PCIS of were determined before and after treatment. 28-day survival rate was compared between the two groups. Results TNF-α and IL-6 were decreased at 24h and 48h and IL-1 was at 48h; the difference was significant (P＜0.05). The indices of circulatory,respiratory,and internal environment stability were obviously improved after treatment (P＜0.05). PCIS score increased (P＜0.05). 28day survival rate was significanfly higer than in the treatment group than in the control group. Conclusions CVVH can effectively remove serum TNF-α,IL-1,and IL-6 in children with MODS,correct disturbance of the internal environment,and improve prognosis. Key words: Continuous veno-venous hemofiltratior; Sepsis; Multiple organ dysfunction syndrome; Children