Abstract
Background This study aims to investigate the clinical efficacy of chemotherapy combined with traditional Chinese medicine in patients with cervical cancer and its effect on cellular immunoglobulin, serum sugar chain antigen 125 (CA125), carcinoembryonic antigen (CEA), and tumor necrosis factor-α (TNF-α). Methods Conventional chemotherapy was performed in control and observation groups. Meantime, the observation group received traditional Chinese medicine. Finally, the clinical efficacy, immunoglobulin, serum tumor markers, and serum TNF-α of the two groups were compared. Results Compared with the control group, total effective rate in the observation group was increased. After treatment, serum CD8+, TNF-α, CA125, and CEA levels were reduced in the two groups, and the observation group was higher. In the two groups, CD3+ and CD4+ levels were enhanced after treatment, and the observation group was also higher. Compared with the control group, the immunoglobulin IgG, IgA, and IgM levels increased in the observation group. The incidence of adverse reactions in the observation group was reduced compared to the control group. Conclusion Chemotherapy combined with traditional Chinese can help improve the clinical efficacy and immunity in patients with cervical cancer. Moreover, the safety and feasibility of the treatment method are relatively high.
Highlights
Cervical cancer (CC) is a common type of gynecological malignant tumor, and its development is a slow and continuous process from quantitative change to qualitative change [1,2,3]. ere can be no symptoms in the early stage of CC
Combined treatment can obviously prevent recurrence and metastasis, reduce the damage of radiotherapy and chemotherapy to the digestive tract and hematopoietic system, and strengthen the effect of radiotherapy and chemotherapy [22,23,24,25,26]. erefore, we explored the clinical efficacy of chemotherapy combined with traditional Chinese medicine in patients with CC and its influence on cellular immunity, serum tumor necrosis factor-α (TNF-α), chain antigen 125 (CA125), and carcinoembryonic antigen (CEA)
A shortterm effect was observed 1 month after treatment. e observation group included 11 CR patients (28.2%), 24 PR patients (61.5%), 3 stable disease (SD) patients (7.7%), and 1 PD patient (2.6%). e clinical efficacy rate was 89.7% (35/39)
Summary
Cervical cancer (CC) is a common type of gynecological malignant tumor, and its development is a slow and continuous process from quantitative change to qualitative change [1,2,3]. ere can be no symptoms in the early stage of CC. Ere can be no symptoms in the early stage of CC. Patients may experience symptoms such as contact bleeding and abnormal vaginal discharge [4, 5]. According to the statistics of global cancer data in 2018, there are more than 560,000 newly diagnosed cases worldwide each year, and the death toll exceeds 310,000 [6]. E causes and pathogenic mechanisms of cervical cancer are very complicated. With the development technology, the cause of cervical cancer has gradually become clear. It has been confirmed that persistent HPV virus is the main cause of cervical cancer [7,8,9,10,11]
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