Abstract
Objective To investigate the clinical value of fibrinogen reference intervals in normal pregnant womem Methods We analyzed and compared fibrinogen results from 12 423 cages of normal pregnant women through previous and present reference intervals.All the results were obtained from a calibrated and QC qualified Sysmex CA-7000 automatic coagulometer.The previous fibrinogen reference interval was from Clinical Laboratory Foundation(The fourth edition).The present fibrinogen reference interval was established through longitudinal study in our laboratory.Consistency checking was applied for the comparison of these reference intervals and decided by the Kappa value.Results The previous Fg reference interval was 2.00-4.00g/L.The present Fg reference intervals of the first,secong,third trimeter and postpartum were 2.73-4.93,2.94-5.00,3.01-5.98,1.76-3.60 g/L respectively.Compared to the previous Fg interval,after using present Fg reference interval the abnormal rate was reduced into 1/4.Through the consistency test,we figured out that Kappa=0.128(<0.4),U=26.825,P<0.05 and these two intervais were inconsistent in criteria iudging.Then we took further analysis for inconsistent data.Totally6 270 cases Were iudged normal by the present interval but abnormal by the previous one,accounting for50.47%.The present Fg reference intervals redueed the abnormal judgment markedly,which was induced by physiological Fg increase.And thus it cut down the misdiagnosis rate;323 cases were juased abnormal by the previous interval but normal by the present one,accounting for 2.6%.Furthermore,there were 303cases lower than the present interval,showing the present Fg reference intervals increased the sensitivity to abnormal low fibrinogen results and reduced the rate of missed diagnosis.Conclusion From an economic point of view,the present fibrinogen reference intervals are more applicable and economic while considering the practicality; the present fibrinogen reference intervals are more sensitive in evaluating the dangers for pregnancy. Key words: Fibrinogen; Reference interval
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