Abstract
The periodic fever, aphthous stomatitis, pharyngitis and adenitis (PFAPA) syndrome is considered as a non-inherited autoinflammatory disease of unknown etiology. The most common clinical manifestations are high fever episodes with clockwork periodicity every 3 to 8 weeks and lasts for about 3 to 6 days, associated to pharyngitis, aphthous stomatitis, and cervical adenitis.
Highlights
The periodic fever, aphthous stomatitis, pharyngitis and adenitis (PFAPA) syndrome is considered as a noninherited autoinflammatory disease of unknown etiology
The mean interval between episodes was statistically prolonged in patients who were on prophylactic colchicine therapy. Both pediatricians and ENT specialist have to keep PFAPA Syndrome in their mind when they encounter with a patient with recurrent fever attacks before starting antibiotics
The colchicine treatment was found effective in decreasing the frequency of fever episodes
Summary
The periodic fever, aphthous stomatitis, pharyngitis and adenitis (PFAPA) syndrome is considered as a noninherited autoinflammatory disease of unknown etiology. The most common clinical manifestations are high fever episodes with clockwork periodicity every 3 to 8 weeks and lasts for about 3 to 6 days, associated to pharyngitis, aphthous stomatitis, and cervical adenitis
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