The clinical characteristics of liver injury in acute pancreatitis complicated with metabolic syndrome

Abstract

Objective To investigate the clinical characteristics of liver injury in patients with Non-biliariogenous acute pancreatitis complicated with metabolic syndrome (MS). Methods There were 63 patients complicated with MS (the MS group) and 145 patients without MS (the non-MS group) hospitalized in our hospital were evaluated. The general conditions, body mass index (BMI), C reactive protein (CRP), blood lipid (TG), blood glucose, alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL) and albumin (ALB) were compared between the two groups. Results BMI, CRP, blood lipid and blood sugar in MS group were significantly higher than those in non MS group (P<0.05). Levels of ALT [(123.4±16.7)U/L vs (63.8±8.5)U/L, P<0.05], AST [(84.7±13.1)U/L vs (55.7±7.1)U/L, P<0.05], TBIL [(32.3±12.9)U/L vs (21.7±10.4)μmol/L, P<0.05] in the MS group were higher than that in the non-MS group (P<0.05). The abnormal liver function in MS group was mostly elevated by AST and TBIL, but only elevation of AST in MS group. Conclusions The incidence of liver injury in patients with non biliary acute pancreatitis combined with metabolic syndrome is high and much heavier. In the diagnosis and treatment of such patients, the changes of liver function should be closely monitored and the active treatment should be strengthened. Key words: Pancreatitis/CO; Metabolic syndrome X/CO; Liver function tests