Abstract
The article described the rare clinical case of the patient with probable transmissible encephalopathy (Creutzfeldt–Jakob disease) in whom rapidly forming primary progressive aphasia was the herald clinical feature, and motor and sensory functions were preserved. Creutzfeldt–Jakob disease was diagnosed, and it was confirmed by clinical picture with fast progression of the disease, together with neurovisualization (brain magnetic resonance imaging, FLAIR and DWI options) and electroencephalography pattern. Other possible causes of primary progressive aphasia were excluded.
Highlights
В описанном клиническом наблюдении пациенту проводили неврологический осмотр в динамике, лабораторные исследования крови, мочи, цереброспинальной жидкости, исследование олигоклонального IgG и свободных легких цепей каппа и лямбда; электроэнцефалографию (ЭЭГ); магнитно-резонансную томографию головного мозга в динамике; кардиологическое обследование – электрокардиографию (ЭКГ), мониторирование ЭКГ, эхокардиографию (Эхо-КГ)
The authors confirm that they respect the rights of the people participated in the study, including obtaining informed consent when it is necessary, and the rules of treatment of animals when they are used in the study
Dunkelberger, Maya Henry et al Geschwind Sporadic Jakob-Creutzfeldt disease presenting as primary progressive aphasia // JAMA Neurol. – 2013. – Vol 70, No 2. – Р. 254–257
Summary
Поступила в редакцию 07.10.18 г.; принята к печати 21.05.19 г.
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