THE CLINICAL CASE OF GENERALIZED CONGENITAL HERPESVIRUS INFECTION IN NEWBORNS, AS A RESULT OF PRIMARY ASYMPTOMATIC INFECTION OF THE MOTHER WITH HSV TYPE 2 DURING PREGNANCY

Abstract

The article presents a clinical case of generalized congenital herpesvirus infection with manifestation on the fourth day of life due to asymptomatic primary infection of the mother with HSV type 2 during pregnancy, complicated by early neonatal bacterial sepsis. The features of the clinic, diagnostics, principles of treatment and follow-up data of the child are presented. Clinical manifestation of congenital herpes infection took place on the 4th day of life. Laboratory confirmed by the detection of DNA of the herpes simplex virus type 2 in the blood, followed by determination of the quantitative level of this indicator and subsequent clinical and laboratory dynamics. Cancellation of specific therapy after 21 days due to the end of the course. Continuation up to 1 year 2 months of a course of specific mmunosuppressive therapy with acyclovir with increased therapy in case of recurrence of local manifestations. At the age of 1 year and 2 months, the withdrawal of specific immunosuppressive therapy. During the next year of life, 4 episodes of recurrence of herpes infection, in the form of local skin lesions. The child was vaccinated according to the calendar, additional vaccination against chickenpox, hepatitis A, pneumococcus, rotavirus infection, seasonal flu. Now the child is 2.4 years old. The child's condition is satisfactory. Development by age. The publication of materials was agreed with the Bioethics Commission of the National Bohomolets Medical University. All anamnestic data, examination results and photo materials were published upon written consent of the parents of the newborn child.Conclusions. Neonatal herpes infection can lead to significant morbidity, mortality, and adverse long-term outcomes. Despiteadequate therapy, vesicular rash recurrences in the first years of life are very common. Given the high rate of herpes simplex virus infection in the population, especially in pregnant women, all children should be considered potentially prone to herpes infection. Determination of maternal immune status, early diagnosis of clinical signs with verification of the causative agent, and timely and adequate specific antiviral therapy are essential to improve prognosis and reduce disability in later years of life.