The clinical biological characteristics of papillary thyroid carcinoma associated with Hashimoto's thyroiditis

Abstract

Objective To analyze the clinical and biological characteristics of papillary thyroid carcinoma(PTC) associated with Hashimoto's thyroiditis(HT).Methods From January 2011 to October 2011,clinical data of 445 PTC patients (97 coexisting with HT) treated at Department of Thyroid and Neck Tumor,Tianjin Medical University Cancer Hospital were retrospectively analyzed.Results In PTC patients coexisting with HT,as compared with those PTC without HT,there were more women patients and more cases with intrathyroid multifocal lesions (all P ＜ 0.05).There were no differences in age,tumor size,extrathyroid extension,lymph node metastasis and TNM stage between the 2 groups.There were lower levels of preoperative serum FT3 and FT4,higher levels of TSH,Anti-TG and Anti-TPO in the HT group (P ＜0.05).Tumor samples of 134 patients was examined for the BRAFV600E mutation.The frequency of BRAFV600E mutation in HT group was lower than that in the papillary thyroid carcinoma group without HT (35.3％ vs.64.0％,P ＜0.01).Conclusions There were more women in papillary thyroid carcinoma coexisting HT group,and multifocal lesions were more common.The high serum TSH levels may be associated with the occurrence of papillary thyroid carcinoma in some HT patients.The frequency of BRAFV600E mutation in the HT group was lower than that in the papillary thyroid carcinoma group without HT. Key words: Thyroid neoplasms ; Carcinoma, papillary; Hashimoto disease; Thyrotropin; Proto-oncogene proteins B-raf