The clinical application of ICG by hypertonic glucose diluting staining to inner limiting membrane to treat idiopathic macular hole

Abstract

Objective To investigate the efficiency, security and convenience of applying ICG by hypertonic glucose diluting staining to inner limiting membrane to treat idiopathic macular hole. Methods Choose 16 cases (16 eyes) of complex vitreoretinal surgery as group 1 and 18 cases (18eyes) as group 2. Group 1 underwent a subtotal pars plana vitrectomy and gas-liquid exchange, then removal of inner limiting membrane by applying ICG staining to inner limiting membrane. Group 2 underwent a subtotal pars plana vitrectomy and removal of inner limiting membrane directly applying ICG by hypertonic glucose diluting staining to inner limiting membrane. Follow up for 3-8 months. Results Both two groups had the removal of inner limiting membrane successfully. The rate of macular hole closure obtained 100% in two groups. The visual acuity and best corrected visual acuity in two groups raised significantly. There were no statistically significant differences in the best corrected visual acuity postoperative between the two groups. The times of removal of inner limiting membrane in group 2 was slower than in the group 1 (P ＜0.05). The postoperative peak amplitude of MERG's second-order response of peripheral retina was significantly lower than that of pre-operative in group 1, but there was not significantly different in group 2. Conclusions Applying ICG by hypertonic glucose diluting staining to inner limiting membrane to treat macular hole is efficient, secure and convenient. Offering a new selection for staining to inner limiting membrane, but the long-term effectiveness, safety and the operation technique need further observation and summary. Key words: Hypertonic glucose; Inner limiting membrane; Indocyanine green; Idiopathic macular hole