Abstract
As an neurotransmitter of non-adrenergic and non-cholinergic nerve, nitric oxide can act on blood vessels and involve in the regulation of bronchial smooth muscle function. Since Alving had firstly found in 1993 that exhaled nitric oxide(FeNO)significantly increased in asthma patients, extensive study of FeNO present. As an non-invasive method, FeNO can be used to evaluate the airway inflammation of children who has respiratory disease and has been widely used in the management of childhood asthma. Many methods can detect FeNO levels, although many factors can affect the test results, but the FeNO seems to have a higher accuracy than pulmonary function and bronchial provocation tests. Currently FeNO also has great significance in the diagnosis, treatment and evaluation of prognosis of children's respiratory disease such as chronic cough, acute respiratory distress syndrome, rhinitis, viral bronchiolitis, community acquired pneumonia, bronchiectasis, bronchiolitis obliterans and diffuse lung diseases. Key words: Exhaled nitric oxide; Airway disease; Children
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