The clinical and pathologic analysis of congenital leukemia(attached six autopsy reports)

Abstract

Objective Congenital leukemia is very rare. We analyzed six death cases of the disease through autopsy. Results Tumor cells widely infiltrated splanchan organs. All cases can see neoplastic cells in heart,liver,spleen,lung,kidney and digestive tract.5 cases in Bone marrow,lymph nodes,thymus,pancreas and adrenal gland.4 cases in brain and thyroid. 3 in bladder.2 in meninges and skin. 1 in glosspharyngeum, testis and uterus respectively. 4 cases were acute lymphocytic leukemia(ALL), 2 were acute myeloid leukemia(acute monocytic leukemia). Immunohistochemically, 4 cases of ALL were positive for CD45RO and CD3, that was T lymphocytic cell immunophenotyping. 1 case of 2 AML was positive for CD68 and Lyso, so the diagnosis may be acute monocytic leukemia. The case had no time to do hematologic research and FAB study, because it survived only one hour after birth. The other was an old case, its bone marrow smear showed FAB-M5, and didn't do immunohistochemistry study.Conclusion Neoplastic cells widely infiltrated splanchan organs in autopsy cases of congenital leukemia, and even can see tumor thrombus in vessels, and metastase through blood. Congenital leukemia is a very early and dangerous disease, and it is difficult for treatment and has a bad prognosis.