The clinical and laboratory characteristics of male patients with antiphospholipid syndrome

Abstract

Objective To investigate the clinical and laboratory features of male patients with anti-phospholipid syndrome (APS). Methods Thirty-three male APS patients admitted to Peking University People's Hospital from January 2003 to April 2015 were enrolled. One hundred and fourteen female APS patients were selected as controls. Female patients with thrombosis were analyzed. χ2 test, Fisher's exact test and t test were used for statistical analysis. Results Among male patients, 39.4% were primary APS and 60.6% were secondary APS. Compare with female patients, the prevalence of venous thrombosis was significantly higher than that in male APS (72.7% vs 29.8%, χ2=19.719, P=0.000). The male APS patients experienced more episodes of thrombosis (75.8% vs 22.8%, χ2=31.669, P=0.000) and not less than two locations of thrombosis than female (69.7% vs 22.8%, χ2=25.321, P=0.000), there was still significant difference between male patients and female patients with thrombosis. There was no difference of antiphopholipid antibodies between the two groups. Conclusion Male patients with antiphospholipid syndrome are more prone to have thrombosis. More clinical interventions should be implemented in male patients with APS. Key words: Antiphospholipid syndrome; Male; Thrombosis