The clinical analysis of thromboembolism in esophagogastric cancer in Japan: A single institute experience.

Abstract

14 Background: Although patients with esophagogastric cancer have a higher risk of thromboembolism (TE), the clinical characteristics of esophagogastric cancer patients with TE remain unclear. Methods: We conducted a retrospective study of who were treated for TE in our institution from January 2014 to August 2017. Results: During this period, 1538 esophaogastic cancer patients received anti cancer therapy. Of these 62 (4.0%) patients diagnosed as having TE during their clinical course. Background of these patitents were median age :64.5 (28-87), gender male/ female: 36 /26, 47 had gastric cancer, 12 esophageal cancer, and 2 gastroesophageal cancer. Performance Status were 0/1/2/3 = 21/24/13/4. Clinical stage were Ⅳ 32 (metastatic sites; lymph nodes 7, peritoneal dissemination 6, ovary 4, liver 1), recurrence 18, and other 12 respectively. 26 patients did not have medical history, 15 had hypertension, 4 had diabetes mellitus, and 4 had hyperlipidemia. Pathologically, adenocarcinoma 50, squamous carcinoma 10, and other 2. Among patients with gastric cancer, 6 (12.8%) showed Her2 overexpression. The median D-dimer levels was 4.81(0.42-17.25) μg/ml. The onset of TE was before starting chemotherapy in 8(12.9%), during receiving chemotherapy in 48(77.4%), and during washout period in 6. On patients who developed TE during receiving chemotherapy, the regimens of chemotherapy were S-1 16, weekly paclitaxel 10 (plus ramucirumab 3), SOX 7, FP 4, Irinotecan 3, SP 3, FOLFOX 3, XP+Trastuzumab3, and others 9. The types of venous thrombosis were deep vein thrombosis 33, pulmonary embolism 23, central venous catheter 7, internal jugular vein 5, subclavian vein 4, and others 5. Four patients suffered cerebral infarction due to thrombosis of the arterial system thrombosis. Initial anticoagulation treatment for TE were heparin 33, warfarin 13, edoxaban 12 and other 4. 29 patients (46.8%) had no symptom related TE. Conclusions: In our analysis, 12.9% patients had TE before starting treatment, we should pay attention to TE immediately after diagnosis of esophagogastric cancer. As 46.8% patients have no symptom related TE, it is important to develop of biomarkers for screening TE, likely D-dimer.