The clinic research of heparin sensitivity between different ethnic groups of the patients with heart surgery

Abstract

Objective To investigate heparin sensitivity and the difference of dosage of heparin during different ethnic groups of the patients with heart surgery.Methods Selecting 293 cases of patients with heart surgery under the general anesthesia extracorporeal circulation,included 109 cases of the Uighurs ethnic group,86 cases of Kazak ethnic group,98 cases of Han ethnic group.Detecting preoperative basis Activated Clotting Time (ACT),giving heparin 2 mg/kg for the first time,adding heparin 0.5 mg/kg to 3.O mg/kg successively,monitoring the ACT of different doses of heparin,recorded the patients,general data,amount of blood transfusion and postoperative 24h flow.Results ACT is different under the different doses of heparin during different ethnic groups of the patients.The ACT of Uighur ethnic and Kazakh ethnic are higher than Han ethnic obviously,there is obvious statistical significance (P ＜ 0.05) ; The comparison of the patients proportion of ACT ＞ 400 s under heparin dose 2 mg/kg during different ethnic groups,Uighur ethnic,Kazakh ethnic and Han ethnic respectively accounted for 82.56％,84.88％ and 77.55％ ; To the postoperative 24 h flow,Uighur ethnic and Kazakh ethnic are less than Han ethnic obviously (P ＜ 0.05),but there is no significance between Uighur ethnic and Kazakh ethnic (P ＞ 0.05).Conclusion There is different sensitivity to the same dose of heparin during different ethnic groups.The sensitivity of heparin in Han ethnic patients is less than Uighur ethnic and Kazakh ethnic patients,and the postoperative blood loss is more than the other two groups. Key words: Different ethnic groups; Heparin ; Sensitivity; Extracorporeal circulation