Abstract
Objective: To study the effect of diclofenac suppository in oocyte retrieval of IVF-ET. Study Design: 1176 patients with informed consents were enrolled into this prospective randomized controlled study. The setting was an IVF-ET program at the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. According to the analgesic drug use, the patients were randomly divided into pethidine group (573 cases) and diclofenac suppository group (603 cases). The data of vital signs, common adverse reactions, severe adverse events and pain degree in oocyte retrieval were collected. The IVF-ET outcomes were also compared. Results: The post-operation pressure and pulse were lower in pethidine group than in diclofenac suppository group (both P0.001).The rest vital signs were not statistically different (all P>0.05). Common adverse reactions in diclofenac suppository group were relative less (all P0.05). Pain degree between the two groups was not statistically different (P=0.304). IVF-ET outcomes were also not statistically different (all P>0.05). There were 3 cases serious abdominal bleeding with shock in the diclofenac suppository group. Conclusion: Using diclofenac suppository in oocyte retrieval analgesic had a good effect. And there was no adverse effect in the IVF-ET outcome. But we should pay close attention to the probability of serious abdominal bleeding.
Highlights
With the vigorous development of assisted reproductive technology, in vitro fertilization-embryo transfer (IVFET) technique has gradually become the routine method in current infertility treatment
According to the analgesic drug use, the patients were randomly divided into pethidine group (573 cases) and diclofenac suppository group (603 cases)
The post-operation pressure and pulse were lower in pethidine group than in diclofenac suppository group.The rest vital signs were not statistically different
Summary
With the vigorous development of assisted reproductive technology, in vitro fertilization-embryo transfer (IVFET) technique has gradually become the routine method in current infertility treatment. Oocyte retrieval in IVFET protocol is an invasive step, which is often mediated by transvaginal ultrasonography. The surgeries often lead to lower abdominal pain. In many IVF reproductive centers, pethidine is chosen for analgesia in the operation. Other drugs such as propofol, nitrous oxide achieved good results. The pain in some patients has not been effectively alleviated [1]. In some IVF centers, it was used in oocyte retrieval. In order to learn more about the clinical efficacy and safety of this drug in IVF treatment protocols, we carried out this clinical analysis
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