Abstract
A study has been made of the origins of the quantitative theory of simple competitive antagonism as manifest in the papers of Gaddum and of Clark. The classical data of Clark on the antagonism of acetylcholine by atropine were reanalysed by recently developed computer-based methods. It was seen how close Clark came to initiating a method having the following significant advantages over the Schild plot: (i) symmetrical treatment with respect to the control (zero antagonist) data; (ii) absence of difficulty with the cases where an estimated dose-ratio is less than unity; (iii) straightforward calculation of approximate standard errors for departure from overall simple competitivity at each antagonist level including control.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
