Abstract
AbstractMulticellular organisms evolved via repeated functional divergence and subspecialization of transcriptionally related, but distinct sister cell types. In this talk, I describe the cis‐regulatory logic of two canonical sister cell types in the retina: photoreceptors and bipolar cells. Although these cell types have highly divergent transcriptional profiles and open chromatin maps, they share remarkably similar cis‐regulatory grammars. I present evidence that the presence/absence of a single key transcription factor binding site motif played a key role in the evolutionary divergence of the bipolar transcriptome from that of photoreceptors.
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