Abstract
BackgroundLiver cirrhosis is a leading cause of morbidity, premature mortality and acute care utilization in patients with digestive disease. In the province of Alberta, hospital readmission rates for patients with cirrhosis are estimated at 44% at 90 days. For hospitalized patients, multiple care gaps exist, the most notable stemming from i) the lack of a structured approach to best practice care for cirrhosis complications, ii) the lack of a structured approach to broader health needs and iii) suboptimal preparation for transition of care into the community. Cirrhosis Care Alberta (CCAB) is a 4-year multi-component pragmatic trial which aims to address these gaps. The proposed intervention is initiated at the time of hospitalization through implementation of a clinical information system embedded electronic order set for delivering evidence-based best practices under real-world conditions. The overarching objective of the CCAB trial is to demonstrate effectiveness and implementation feasibility for use of the order set in routine patient care within eight hospital sites in Alberta.MethodsA mixed methods hybrid type I effectiveness-implementation design will be used to evaluate the effectiveness of the order set intervention. The primary outcome is a reduction in 90-day cumulative length of stay. Implementation outcomes such as reach, adoption, fidelity and maintenance will also be evaluated alongside other patient and service outcomes such as readmission rates, quality of care and cost-effectiveness. This theory-based trial will be guided by Normalization Process Theory, Consolidated Framework on Implementation Research (CFIR) and the Reach-Effectiveness-Adoption-Implementation-Maintenance (RE-AIM) Framework.DiscussionThe CCAB project is unique in its breadth, both in the comprehensiveness of the multi-component order set and also for the breadth of its roll-out. Lessons learned will ultimately inform the feasibility and effectiveness of this approach in “real-world” conditions as well as adoption and adaptation of these best practices within the rest of Alberta, other provinces in Canada, and beyond.Trial registrationClinicalTrials.gov: NCT04149223, November 4, 2019.
Highlights
Liver cirrhosis is a leading cause of morbidity, premature mortality and acute care utilization in patients with digestive disease
Aims and objectives The primary aim of this study is to evaluate the effectiveness of the Cirrhosis Care Alberta (CCAB) order set intervention in reducing 90-day cumulative length of stay (LOS)
Phase 3 – implementation The final phase of the study will commence with “go-live” of the CCAB order set in the provincial clinical information system (CIS) at each site
Summary
Liver cirrhosis is a leading cause of morbidity, premature mortality and acute care utilization in patients with digestive disease. Liver cirrhosis is a chronic condition that results from vascular and hepatocellular injury, and leads to progressive hepatic fibrosis It is a major cause of morbidity and premature mortality in patients with digestive disease [1, 2]. In a recent prospective cohort study of 14 centers across North America, 90-day readmission rates were reported at 53% [14] This data parallels provincial Alberta Health Services (AHS) administrative data for a 1-year period (2015–2016) which revealed readmission rates of 44% at 90 days [14] (Carbonneau M, Davyduke T, Tandon P, Ma M, Den Heyer V, Newnham K, et al: Impact of Specialized Multidisciplinary Care on Cirrhosis Outcomes and Acute Care Utilization, unpublished).
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