Abstract
The integrity of the circulation depends on the summation of the effects of the cardiac output, the peripheral vascular resistance, and the blood volume. Agents producmg general anaesthesia affect the circulation by decreasing cardiac output and peripheral resistance, this effect is in proportion to the concentration of agents in the blood. Other factors which may alter the circulation in anaesthesia are the status of ventilation, the degree of hypoxia, the administration of relaxants, and the occurrence of metabolic acidosis. Along with the usual clinical means of evaluating the circulation, venous pressure values are helpful data. These values permit differentiation between a problem in which myocardial function needs improvement and one in which blood volume can be safely increased to treat an inadequate circulation.
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