Abstract
Circular dichroism and optical rotatory dispersion curves of protoberberines and the corresponding benzyltetrahydroisoquinolines have been measured. Allotment of absolute configuration cannot be made by direct comparison between members of the two series, since for the same absolute configuration the two series show curves of opposite signs.Protoberberine alkaloids are formed by the Mannich reaction of benzyltetrahydroisoquinolines with formalin. This reaction gives products of high optical purity, and can therefore be used for the allotment of configuration to protoberberine alkaloids. The stability of the asymmetric centre was confirmed in the present work; tetrahydropapaverine labelled with deuterium at C-1 retained the isotope during the Mannich reaction.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
