Abstract
ABSTRACT A method for the investigation of the cortisol rhythm, estimating the free cortisol in 2-hr urine samples, is described. In each of 7 normal individuals highly reproducible curves with circadian rhythm could be found. Due to differences in the time of the morning peak the mean curve of the normal individuals resembles the individual curves only after synchronizing them according to the morning peak. In this peak sample the cortisol excretion rate is 2½ times higher than during the remainder of the day. Eight severely obese patients did not differ from the control subjects in their circadian rhythm: the difference in the absolute daily cortisol excretion (obese patients: 29.1 normal subjects: 46.3 μg/24 hr) probably represents the difference between hospitalized and nonhospitalized persons. Six patients with Cushing's syndrome due to bilateral adrenal hyperplasia exhibited a great heterogeneity with the following observations in different patients: very uneven curves without a distinct pattern, di...
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