Abstract
AbstractThe activity of acid phosphatase and the content of Pi1 were estimated in kidney homogenates from male and female mice. The determinations were repeated at 6‐hr intervals during the day, starting at noon, using control animals and animals previously subjected to a high dose of UV radiation. Marked changes in the activity of this enzyme were found during the course of the day, indicating the existence of a circadian rhythm. This phenomenon is observed both in males and in females and exhibits similar features in both sexes. The content of Pi in the kidney homogenate varies in an analogous manner. UV irradiation produced significant changes both in the enzyme activity and in the content of inorganic phosphate. In irradiated animals the new maxima in the activity of acid phosphatase were generally accompanied by maxima in the amount of Pi. It is supposed that the end products of the reactions in the skin formed under the influence of UV radiation and associated with the degradation of phospholipids are the main factors responsible for the observed changes in the kidney.
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