Abstract

Rapid separation of mixtures of benzodiazepine drugs was achieved using a thin-layer system based on alumina, complemented by a silica gel loaded paper system. Location of the spots was by short-wavelength ultraviolet light and acidified potassium iodoplatinate. The compounds examined were Chlordiazepoxide, Diazepam, Nitrazepam, Oxazepam, Bromazepam, Medazepam and Dibenzepine. Their behaviour to ultraviolet light of wavelength 254nm and 350nm under neutral, acid and alkaline conditions was examined in the form of spot tests on filter paper.

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