THE CHOICE OF ANTIDEPRESSANTS FOR THE TREATMENT OF DEPRESSIVE DISORDERS ASSOCIATED WITH EPILEPSY

Abstract

The prevalence of depression (D) in patients with epilepsy (PE) is quite high and 12-37% due to common neurobiological structural and morphological and neurotransmitter mechanisms underlying these diseases. Depression negatively affects the quality of life and control of seizures in PE is associated with a high risk of suicidality in PE, the disease is poorly diagnosed the PE shall be appointed and rarely antidepressants (AD) for the treatment D in PE. Materials and Methods. The aim of our prospective observational study with an active control was to evaluate the clinical efficacy and safety of AD the second generation – of escitalopram in the treatment of depressive disorders in 30 PE with D. The control group consisted of 30 PE not receiving AD. Evaluation of the effectiveness of treatment in PE with D was carried out at three points (baseline, after 3 and 6 months of treatment AD) by depression rating score using psychometric scales and scales assessing the overall clinical impression of the gravity of the violations. Results. In the PED group, treated with AD significantly decreased the values of D, there was a decrease in the severity and frequency of seizures, improvement in the overall clinical impression, while distinct trends in these indicators in the comparative group were note. Conclusion. Our findings confirm the need for early detection of D in PE and destination AD with a harmonious profile of efficacy and safety.