Abstract
. The authorshave implemented an isolated canine perfused right atrialpreparation—appended to a rim of right ventricular tissue—and recorded atrial and ventricular transmembrane actionpotentials and pseudo-electrograms before and after intra-coronary perfusion of various concentrations of WenxinKeli. Interestingly, Wenxin Keli produced effects more no-ticeable in atrial tissue than in ventricular tissue, as it causedaction potential duration (APD) shortening and postrepolar-ization refractoriness—which is a prolongation of effectiverefractory periods without APD prolongation—in an atrial-selective manner. In addition, Wenxin Keli produced agreater reduction in the maximum rate of rise of the actionpotential upstroke and a larger increase in the diastolicthreshold for excitation in atrial vs ventricular cells, sug-gestive of I
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