The Chemopreventive Potential and Anti-inflammatory Activities of Korean Black Ginseng in Colon26-M3.1 Carcinoma Cells and Macrophages

Abstract

We investigated the chemopreventive and anti-inflammatory activity of Korean black ginseng (BG) in colon26-M3.1 carcinoma cells and macrophages (in vitro) compared with white ginseng (WG). Both WG and BG had no significant inhibitory effect on normal splenocytes, but on colon26-M3.1 carcinoma cells, BG showed significantly greater inhibitory effect than that of WG. Treating with either WG or BG extracts, the release of TNF-α was significantly decreased in response to lipopolysaccharide as compared with untreated control.