Abstract
The high-fat, low-carbohydrate (ketogenic) diet has grown in popularity in the last decade as a weight loss tool. Research into the diet’s effects on the body have revealed a variety of other health benefits. The use of exogenous ketone supplements to confer the benefits of the diet without strict adherence to it represents an exciting new area of focus. Synthetic ketogenic compounds are of particular interest that has received very little emphasis and is an untapped area of focus for chemical synthesis. In this review, we summarize the chemical basis for ketogenicity and opportunities for further advancement of the field.
Highlights
Muscle as glycogen, and for the conversion of glucose to glycerol.of triacylglycerides from thefor hydrolysis triglycerides) toelectron-transport be in the biosynthesis cle as glycogen, and the conversion of glucose to used glycerol
Typical lead to a decreased incidence or even the elimination of epileptic ketone body concentrations during dietary ketosis are between 0.5–3
Related to the benefits of weight loss, the ketogenic diet has been shown to improve and even reverse insulin resistance in those suffering from type 2 diabetes or for those who are at risk of becoming diabetic [48,49]
Summary
The ketogenic diet, a high-fat, low-carbohydrate diet, has a long history of use beginning primarily as a treatment option for epilepsy [1,2]. It is only in the last few decades that the diet has been popularized among the general public. Difficulty in adherence to the ketogenic diet is often cited as a reason why it is abandoned due to limited food options. If these obstacles can be overcome, a wide array of possibilities may open up.
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