Abstract

AbstractN‐Methylisatoic anhydrides react with the lithium enolate of ethyl methoxyacetate at low temperatures to produce intermediates which, when cyclized, afford 4‐hydroxy‐3‐methoxy‐2(1H)‐quinolinones. By this route, 3‐methoxy‐N‐methylisatoic anhydride (8) can be converted to the alkaloid swietenidin A (2) in 71% yield.

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