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Abstract
Molecular diversity as a source of potential drug candidates has been an area of tremendous growth during the past year. The field has been dominated by investigations featuring diverse peptide libraries, generated by both chemical and biological methods. Yet the many undesirable properties of peptides as drugs, such as poor oral availability and low in vivo stability, have prompted chemists to develop methods for the efficient synthesis of conformationally constrained peptide, biopolymer and non-polymeric compound collections.
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