Abstract

A play titled Elegance molekuly (The elegance of the molecule) is performed twice a month in the Czech Republic capital of Prague. Recounting the accomplishments of Antonin Holý, a chemist who discovered the compound that led to Truvada—Gilead Sciences’ breakthrough HIV/AIDS therapy—the play sells out weeks in advance. Holý, an eminent figure in the Czech science community for his work on nucleotide analog synthesis, died in 2012 at the age of 75. The Czech Republic issued a stamp in his honor. Holý’s work is important in a country that was looking for heroes during its long rebound from the repression of Soviet dominance after World War II. His achievements shine a light on the Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB), where he did his research, showcasing the strength of chemistry in the country. Czech chemistry has a heritage that stretches back more than

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