Abstract
AbstractSeven known compounds, including two neolignans, four lignans, and one flavane were isolated from the methanol extract of Pandanus tonkinenis fruits. Their structures were determined to be ficusal (1), vladinol F (2), medioresinol (3), syringaresinol (4), lariciresinol (5), secoisolariciresinol (6), and luteoliflavan (7) by analysis of MS and NMR data as well as by comparison of their spectral data with those reported in the literature. All compounds were evaluated for NO production inhibitory and lipid peroxidative inhibitory activities. Compounds 5 and 7 showed significant NO production inhibitory with IC50 values of 5.3±0.4 and 7.1±0.4 μM, respectively. Compounds 6 and 7 showed significant lipid peroxidative inhibitory activity with IC50 values of 20.2±1.7 and 26.2±3.6 μM, respectively.
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