Abstract
The present work was designed to investigate the characterization, as well as the antioxidation and renoprotection in streptozocin (STZ)-induced diabetic mice, of exopolysaccharides (EPS) and the enzymatic-EPS (EEPS) and acidic-EPS (AEPS) hydrolysates, which were separated from the fermentation liquor of Hypsizigus marmoreus. Animal results demonstrated that EPS, EEPS and AEPS had potential antioxidant and renoprotective effects, especially EEPS. Additionally, they were the most effective, reflecting increases in superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT), total antioxidant capacity (T-AOC), and albumin (ALB) of 168.33%, 124.8%, 268.17% 179.49%, and 68.71%, respectively, and decreases in the contents of malondialdehyde (MDA), lipid peroxide (LPO) and levels of serum urea nitrogen (BUN) and creatinine (CRE) by 70.58%, 58.43%, 23.97% and 29.60%, respectively, at a dose of 800 mg/kg compared to those of model mice. Three polysaccharides ameliorated the histopathological alterations which were observed in the kidney of diabetic mice. Furthermore, the characterization of polysaccharides had been expressed. These findings indicated that the EEPS from H. marmoreus possesses more effective renoprotection and antioxidation effects and provided insight into its potential clinical values on preventing diabetes.
Highlights
Chemical-synthetic medicaments, which are widely used clinically in curing many diseases, can cause serious cellular damage in the intracorporeal organs, including the heart, liver, kidney, and pancreas, and previous literature has indicated that these chemicals can be metabolically activated into highly reactive free radical compounds, which can induce oxidative stress, resulting the aggravation of disease progress[1]
For mice in the high-dose (800 mg/kg) EEPS group, the body weight was close to the normal group and increased by 41.80% compared with the model control group (MC) mice
The GLU level in the experiment group treated with EEPS at dose of 800 mg/kg decreased by 50.38% compared to those of the MC mice
Summary
Chemical-synthetic medicaments, which are widely used clinically in curing many diseases, can cause serious cellular damage in the intracorporeal organs, including the heart, liver, kidney, and pancreas, and previous literature has indicated that these chemicals can be metabolically activated into highly reactive free radical compounds, which can induce oxidative stress, resulting the aggravation of disease progress[1]. The macrofungi of mushrooms, the most popular natural food, owing to its special mouthfeel and abundant nutrition, have gained increasing academic attention They were widely used in identifying innovative drugs due to their vast bioactive compounds, such as proteins, polysaccharides, helvolic acid, and p-terphenyls. Numerous literature has demonstrated that polysaccharides, the most varied nutrient dense and abundant substances, have potential biological properties, such as the antioxidants of Tricholoma mongolicum Imai[6], the antitumor compounds of Lentinus edodes[7], and the anti-hyperlipidemic compounds of Termitomyces albuminosus[8] In this regard, the polysaccharides from H. marmoreus, one of the most widely used traditional Chinese medicines and nutritional mushrooms, have attracted much attention because of its multiple pharmacological effects, including as antioxidant, anti-tumor, antiviral compounds and for their immunomodulating properties[9]. The exploration of fermentation liquor and the utilization of fermentation liquor-derived and value-added products, seem to be significant
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
