Abstract
The determination of the composition of PVP-PVAc copolymers and blends is essential for knowing their polymeric properties and appropriate applications. In order to create a streamlined way to quantify the composition of PVP-PVAc copolymers and blends, the qNMR methodology alongside FTIR and elemental analysis were used to develop calibration curves for industrial use. We report on the methodologies used to determine % PVP content in the copolymers and blends in question as well as the results obtained via NMR, FTIR, and elemental analysis. Results from the NMR analysis were corroborated with calibration curves used to determine % PVP composition using FTIR and were further corroborated with elemental analysis results. The PVP-PVAc copolymers used ranged from 30 to 70 mol% PVP and the blends ranged from 20 to 80 weight% PVP.
Highlights
Proton Nuclear Magnetic Resonance Spectroscopy and Fourier Tranform Infrared Spectroscopy have been frequently used for qualitative and quantitative analysis of organic compounds and polymers [1,2,3,4,5,6,7,8,9]
PVP-PVAc copolymers have been used in order to increase the dissolution of drugs that are less soluble in water than desirable such as indomethacin, tolbutamide, and nifedipine [11,12,13,14]
Due to the fact that PVP-PVAc copolymer usages vary based off the copolymer composition, it is of critical importance to develop a toolset that will allow industry leaders to determine their products copolymer ratio for quality control purposes
Summary
Proton Nuclear Magnetic Resonance Spectroscopy and Fourier Tranform Infrared Spectroscopy have been frequently used for qualitative and quantitative analysis of organic compounds and polymers [1,2,3,4,5,6,7,8,9]. The copolymer composition of PVP-PVAc copolymers has not been investigated far with proton NMR. These copolymers have a wide variety of practical applications in various industries including drug delivery, cosmetics, hair-styling, etc. PVP-PVAc copolymers have been used in order to increase the dissolution of drugs that are less soluble in water than desirable such as indomethacin, tolbutamide, and nifedipine [11,12,13,14]. These copolymers have been used to formulate the aforementioned drugs by means of hot melt extrusion as glass solutions and the results consistently show higher bioavailability [10]. In addition to copolymers of PVP-PVAc, blends were analyzed via FTIR and NMR and these ranged from 20 – 80 weight % PVP
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Journal of Polymer and Biopolymer Physics Chemistry
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
