Abstract
Although methylphenidate has been used for decades as a leading treatment for behavioral disorders such as attention deficit hyperactivity disorder (ADHD). Recently it has been used as a cognitive enhancer and for recreation. The mechanism underlying its actions is still unrevealed. Enhancement of mental function by prescription psychostimulants that promise to improve mental performance, attention, memory, planning, etc., is now wide spread. Moreover, in the last two decades stimulants such as MPD have been prescribed to very young children and adults for treating behavioral disorders such as ADHD. This study aims to provide a short review of methylphenidate’s effect on the animal’s behavior.
Highlights
Pyschostimulant medication such as amphetamine was used to treat attention deficit hyperactive disorder (ADHD) patients from 1930’s until it was found it elicits dependency
MPD is a central nervous system (CNS) stimulant that closely relates to the structure of dextroamphetamine [2], a derivative of amphetamine
MPD is highly effective in treating ADHD [3] and useful in providing relief from intractable pain in narcolepsy and chronic fatigue
Summary
Pyschostimulant medication such as amphetamine was used to treat attention deficit hyperactive disorder (ADHD) patients from 1930’s until it was found it elicits dependency. MPD is an indirect catecholamine (CA) agonist since it does not stimulate the catecholaminergic receptors directly but rather facilitates the action of the CA [2] The therapeutic effect of MPD in the treatment of ADHD has been attributed to its ability to increase the efflux of these neurotransmitters. This causes increases in extracellular DA, NA, and 5HT levels [4], which has an effect that has been linked to its reinforcing properties. Their euphoric effects usually occur when they are crushed and snorted or injected
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