Abstract
BackgroundThe current coronavirus disease 2019 (COVID-19) is a public health emergency. In this study, we aimed to evaluate the risk factors for mortality in severe and critical COVID-19 patients.MethodsWe performed a retrospective study of patients diagnosed with severe and critical COVID-19 from four hospitals in Wuhan, China, by evaluating the clinical characteristics and laboratory results, and using Cox proportional hazards model to assess the risk factors involved in disease progression.ResultsIn total, 446 patients with COVID-19 were enrolled. The study indicated a high mortality rate (20.2%) in severe and critical COVID-19 patients. At the time of admission, all patients required oxygen therapy, and 52 (12%) required invasive mechanical ventilation, of which 50 (96%) died. The univariate Cox proportional hazards model showed a white blood cell count of more than 10 × 109/L (HR 3.993,95%CI 2.469 to 6.459) that correlated with an increased mortality rate. The multivariable Cox proportional hazards model demonstrated that older age (HR 1.066, 95% CI 1.043 to 1.089) and higher white blood cell count (HR 1.135, 95% CI 1.080 to 1.192) were independent risk factors for determining COVID-19 associated mortality.ConclusionsCOVID-19 is associated with a significant risk of morbidity and mortality in the population. Older age and higher white blood cell count were found to be independent risk factors for mortality.
Highlights
The current coronavirus disease 2019 (COVID-19) is a public health emergency
In order to explore the onset of clinical characteristics of COVID-19 and assess the prognostic risk factors for patients, we conducted laboratory tests for 446 patients, evaluated the short-term results, and tried to identify the possible clinical consequences and final outcome of the patients
General characteristics The median age of the 446 patients included in the study was 55 years (IQR 42–66); of which, 213 (47.76%) were male, 90 (20.2%) died during hospitalization, and 356 (79.8%) were discharged
Summary
We aimed to evaluate the risk factors for mortality in severe and critical COVID-19 patients. Isolation of bronchoalveolarlavage samples from patients with pneumonia in human airway epithelial cells and subsequent whole-genome. (MERS -CoV), which occurred in 2013, belongs to the same beta-coronavirus genus of coronaviruses as SARSCoV-2 [7, 8]. They are highly pathogenic and the infection manifests as a severe acute respiratory disease [9]. In order to explore the onset of clinical characteristics of COVID-19 and assess the prognostic risk factors for patients, we conducted laboratory tests for 446 patients, evaluated the short-term results, and tried to identify the possible clinical consequences and final outcome of the patients
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