Abstract
The characteristics of a canine mammary carcinoma cell line, REM 134.
Highlights
THE DOG has been widely used as an experimental animal for the assessment of human contraceptive and related drugs, writh special reference to the relative risk of mammary carcinogenesis from such compounds (El Etreby & Graf, 1979)
Owen and co-workers reported the probable establishment of 2 cell lines: one, derived from a primary adenocarcinoma, was fibroblastic in nature, while the second, from a lung metastasis, was epithelial in nature
The bitch was killed 1 month after mastectomy and metastatic tumours involving the liver, diaphragm and lungs were seen at necropsy performed 6 h post morteiii
Summary
THE DOG has been widely used as an experimental animal for the assessment of human contraceptive and related drugs, writh special reference to the relative risk of mammary carcinogenesis from such compounds (El Etreby & Graf, 1979). This report describes the cultural and other characteristics of a cell line (REM 134) derived from a spontaneous primary canine carcinoma (Hampe & Misdorp, 1974). These latter structures are similar to intracytoplasmic duct-like vacuoles described in some human breasttumour cell lines and primary tumotrs (Buehring & Hackett, 1974), and this is indicative of mammary epithelial origin.
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