Abstract
AimIn the present investigation, vancomycin (VCM) biodegradable nanoparticles were developed for oral administration, with the aim of improving its intestinal permeability. MethodsThe vancomycin-loaded nanoparticles were prepared using double-emulsion solvent evaporation method. The prepared nanoparticles were characterized for their micromeritic and crystallographic properties, particle size, zeta potential, drug loading and release. Intestinal permeability of VCM nanoparticles was determined in different concentrations using SPIP technique in rats. ResultsParticle sizes were between 450nm and 466nm for different compositions of VCM-PLGA nanoparticles. Entrapment efficiency ranged between 38.38% and 78.6% with negative zeta (ζ) potential. The FT-IR, XRPD and DSC results ruled out any chemical interaction between the drug and PLGA. Effective intestinal permeability values of VCM nanoparticles in concentrations of 200, 300 and 400μg/ml were significantly higher than that of solutions at the same concentrations. ConclusionOur findings suggest that PLGA nanoparticles could provide a delivery system for VCM, with enhanced intestinal permeability.
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