Abstract
The antioxidant and multiple organ protection effects of acid- extracted mycelia polysaccharides (Ac-MPS) from Pleurotus eryngii var. tuoliensis on HFE-induced hypertriglyceridemic mice were investigated. The results showed that Ac-MPS have potential ability to relieve the hypertriglyceridemia and preventing oxidative stress by decreasing levels of TG, TC LDL-C, elevating contents of HDL-C in serum, increasing the activities of SOD, GSH-Px, CAT and T-AOC, and the down regulating MDA and LPO contents in liver, heart, kidney and spleen. And the histopathological observations also displayed that Ac-MPS could alleviate organ damage. Moreover, the GC, HPGPC, FT-IR and AFM analyses revealed the Ac-MPS possessed the typical polysaccharides structure with the molecular weights (Mw) of 2.712 × 105 Da. These conclusions indicated that the Ac-MPS had the potential to develop new drugs for hypertriglyceridemia-induced multiple organ failure.
Highlights
The hypertriglyceridemia (HTG), clinically reflected by fasting blood triglyceride (TG) levels over than 150 mg/dL, is a common lipid metabolic disorder disease with possibly pathogenic mechanisms including internal genetic factors as well as external factors of obesity, excess alcohol intake, presence of metabolic syndrome, insulin resistance, medications, pregnancy, endocrine diseases and autoimmune diseases[1]
It is a desirable need for exploring the acidic-extractable mycelia polysaccharides (Ac-MPS) from P. eryngii var. tuoliensis
These data suggested that glucose was predominant monosaccharides in Ac-MPS
Summary
The hypertriglyceridemia (HTG), clinically reflected by fasting blood triglyceride (TG) levels over than 150 mg/dL, is a common lipid metabolic disorder disease with possibly pathogenic mechanisms including internal genetic factors as well as external factors of obesity, excess alcohol intake, presence of metabolic syndrome, insulin resistance, medications, pregnancy, endocrine diseases and autoimmune diseases[1]. The SOD, GSH-Px, CAT, and T-AOC activities of Ac-MPS in liver, kidney and spleen expressed dose-dependently.
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