Abstract
Given advances in oncological treatments, cancer rehabilitation physicians should be aware of their potential side effects on the peripheral nervous system and the evolving role of electrodiagnostic testing (EDX). Immune checkpoint inhibitors may cause severe neuromuscular side effects. Novel methods of radiation delivery (hypofractionated and single-fraction radiation) may also lead to nerve and muscle injury. Recent advances in diagnosis and treatment of paraprotein-related neuropathies are important to recognize. EDX is an essential diagnostic tool utilized by clinicians evaluating and treating neuromuscular complications of cancer and its treatment. New cancer-directed treatments may lead to unique patterns of nerve and muscle injuries requiring skilled electrodiagnostic evaluation. Detailed knowledge of the patient’s oncological diagnosis and anti-cancer treatments received in addition to EDX help solidify the diagnosis and guide treatment and prognosis. Patients may also develop neuromuscular conditions unrelated to their cancer and its treatment.
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