Abstract
<h2>Summary</h2> Problems in the serodiagnosis of viral infections have been discussed and illustrated by appropriate examples. While the first infection with a member of a given group of viruses often leads to a strain-specific or type-specific antibody response, subsequent infections with other members of that group may recall antibodies from earlier experiences and lead to a general broadening of antibody spectra. In the face of such multiple antibody responses, a specific diagnosis cannot be made unless the offending virus is isolated from the patient. Attempts at isolation of virus should, therefore, constitute the primary approach to the diagnosis of viral infections.
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