Abstract
To investigate the clinical value of changes in the subtypes of peripheral blood lymphocytes and levels of inflammatory cytokines in patients with COVID-19, the total numbers of lymphocytes and CD4+ lymphocytes and the ratio of CD4+/CD8+ lymphocytes were calculated and observed in different groups of patients with COVID-19. The results show that the lymphocytopenia in patients with COVID-19 was mainly manifested by decreases in the CD4+ T lymphocyte number and the CD4+/CD8+ ratio. The decreased number of CD4+ T lymphocytes and the elevated levels of TNF-α and IL-6 were correlated with the severity of COVID-19 disease.
Highlights
Novel coronavirus pneumonia (NCP) is mainly transmitted through respiratory droplets and close contact
To investigate whether the peripheral blood lymphocytopenia in COVID-19 patients was mainly caused by the decrease in CD4+ T lymphocytes, in this study, patients admitted to our hospital with different severities of COVID-19 were examined as subjects
The results showed that the lymphocytopenia in patients with COVID-19 was mainly manifested by the decrease in CD4+ helper T lymphocytes; in addition, the ratio of CD4+/CD8+ lymphocytes decreased, which showed a typical cellular immune dysfunction similar to that observed in human immunodeficiency virus (HIV) patients
Summary
Novel coronavirus pneumonia (NCP) is mainly transmitted through respiratory droplets and close contact. Characteristic chest CT imaging patterns, positive nucleic acid detection in nasal and throat swab samples, normal or decreased numbers of peripheral white blood cells, decreased numbers of lymphocytes and increased levels of inflammatory cytokines are the key factors in the diagnosis of COVID-19 [3]. CD4+ lymphocytes and inflammatory cytokines in Patients with COVID-19 and CD3+CD8+ cytotoxic T lymphocytes (CD8+ T lymphocytes). To investigate whether the peripheral blood lymphocytopenia in COVID-19 patients was mainly caused by the decrease in CD4+ T lymphocytes, in this study, patients admitted to our hospital with different severities of COVID-19 were examined as subjects. The total number of lymphocytes, the percentages of lymphocyte subtypes and the levels of inflammatory cytokines (TNF-α and IL-6) secreted by CD4+ helper T lymphocytes in the peripheral blood were detected by hematology counter and flow cytometer, respectively. The number of CD4 + lymphocytes and the ratio of CD4+/CD8+ lymphocytes were calculated and observed, and a new method for studying the mechanism of 2019-nCoV-induced lymphocyte reduction was provided
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