Abstract
Background. Obesity is associated with changes in energy homeostasis (irisin and adipokine) and the adipokine system (FABP 4 and CTRP 3) and the impact on the development and course of cardiovascular diseases. The purpose of the study. To investigate the time course of markers of energy homeostasis, adipokines and carbohydrate metabolism and their relationship in patients with acute myocardial infarction with the presence and absence of comorbid pathology. Materials and methods. The study involved examination of 189 patients with acute myocardial infarction with the presence and absence of obesity. The control group included 20 practically healthy subjects. Adropin, irisin, FABP 4, CTRP 3, insulin were determined by enzyme-linked immunosorbent assay. Results of the study. All groups of patients in the time course of observation were found to have a decrease in levels of glucose, insulin, HOMA index (p˂0.05). An increase in adropin, irisin and CTRP 3 and a decrease in FABP 4 in all groups of patients compared with patients by 1-2 days (p˂0.05) were determined on day 10. The relationship between carbohydrate metabolism and adropin, irisin, FABP 4, CTRP 3 in all groups of patients on days 1-2. Conclusion. Our findings indicate that the markers of energy homeostasis and adipokine system influence the state of carbohydrate metabolism in patients with acute myocardial infarction with concomitant obesity was determined.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
